The Save the Children charity aims to reduce by two-thirds the number of children who die under the age of five in more than 40 countries, including South Africa.
Through its global Newborn Survival Campaign, the charity wants to reduce the nine million child deaths a year from HIV and AIDS, other illnesses, childbirth complications and malnutrition.
In South Africa, 75000 children under five die each year - 260 a day.
About 20000 babies are stillborn and 22000 die before they are a month old.
At least 57% of child deaths in South Africa are related to HIV/Aids.
Quereshni Naidoo, campaign manager for Save the Children SA, said: "I am really excited about the launch and hope that we will continue to work with the government. We want to ensure that policies are implemented to save our children."
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